

Can’t read the whole article due to paywall. Here are 2 thoughts for the half that i did read.
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colorectal cancer makes a lot of sense as a target. it still is one of the most cancers with the highest mortality. At the same time we saw an uptick in colorectal cancer rates in young people (reason unknown, maybe microplastics maybe something else.). Furthemore colorectal cancer seems to be a great target for immunsystem modulating therapy. There was a paper 3 years bake in I think the NEJM where they put 18/18 (exact N not sure) patients in remission with PD-1 modulation which also activates the immun system.
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Astra Zeneca (I believe) is also working on a mRNA vaccine for cancer that is quite far along. They are targeting melanoma in remission and reduced reoccurence of melanoma or metastasis after 3 years by 50%. So it seems like mRNA cancer vaccines will be a strong pillar for future cancer treatements.
Sadly we saw in the past that russia sometimes bolsters their numbers for medication efficency. I hope it is not the case this time but i hope that the phase 2/3 trials will be very transparent to quench any doubts.
Why? Seems like a reasonable amount. In the boxes i used there was place for i believe 80 tips so when i had to pipet something in a 96well plate with multiple components that where not able to be mixed before i sometimes got through multiple boxes in a single session. (And yes i wish i had a digital multi pipet but even then it would not have alwqys been possible to use it.