Yes definitely, you can play it without knowing anything about the other games. All you’ll miss out on are references and lore stuff.

Poultrygeist, it’s my favourite film to put on when I want my friends to leave Hahaha.

2 that come to mind are Adom and caves of qud are very similar in terms of designs and inspirations but share very little in common graphics wise are from being all 2d-esque. You can explore dungeons in a roguelike fantasy world.