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Cake day: April 12th, 2025

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  • I think you are both overestimating the ability of biological systems and underestimating the ability of mechanical systems to be repaired.

    Biological systems have incredible self-repair capabilities, but are otherwise largely unrepairable. To fix issues with biological systems you mostly have to work within the bounds of those self-repair mechanisms which are slow, poorly understood and rather limited.

    Loosing a few skin cells is perfectly normal. Corrupting a few skin cells can cancer cancers or autoimmune disorders. Loosing a few Purkinje cells can lead to significant motor impairment and death.

    Computers, and mechanical systems in general, can have a shit ton of redundancy. You mention ECC, but neglected to mention the layers of error connection, BIST, and redundancy that even the cheap, broken, cost-optimized, planned obsolescence consumer crap that most people are mostly familiar with make heavy use of.

    A single bit flipped by a gamma ray will not cause any sort of issue in any modern computer. I cannot overstate how often this and other memory errors happen. A double bit flip can cause issues in a poorly designed system and, again, are not just caused by cosmic rays. However, it’s not usually that hard to have multiple redundancies if that is a concern, such as with high altitude, extreme environment, highly miniaturized, etc. objects. It does increase cost and complexity though so____

    The huge benefit of mechanical systems is they are fully explainable and replaceable. CPU get a bunch of radiation and seems to be acting a bit weird? Replace it! Motor burnt out? Replace it! The new system will be good as new or better.

    You can’t do that in a biological system. Even with autografts (using the person’s own tissues for “replacements”) the risk of scarring, rejection and malignancy remains fairly high and doesn’t result in “good as new” outcome, but is somewhere between ‘death’ and ‘minor permanent injury’. Allografts (doner tissues) often need lifelong medications and maintenance to not fail, and even “minor” transplants carry the risk of infection, necrosis and death.





  • The implications are the variables are conflated and the conclusions are overblown.

    It should come as no surprise that acute trauma and injecting a foreign substance would cause a relatively significant immunological response. The issue is that for the “chronic phase”, which is where the novelty of this research lies, the evidence shown is far from difinitive compared to the story being told and what results are shown aren’t overly significant.

    Even if you 100% believe the paper the conclusion is that the effect of getting tattooed is, arguably, similar to catching the flu once. However, the paper itself tried to obfuscate that so they have a more impactful result and the marketing/outreach/media site that was linked here doubles down on it trying to sell the story of “tattoos==illness and death”!!!



  • The full paper is here and, as usual, it’s hardly anything and decontextualized in order to get a publishable result.

    This one is so bad that it doesn’t use established baselines or do any form of statistical analysis on the results instead opting for their own “baseline” measurements using very small sample sizes. It also plays a smoke and mirrors game where it shows a result for short term immunological response and then uses that to insinuate the ‘slightly reduced but still likely well within the error of the poor control’ long term effects are worth noting.

    Other major flaws:

    • As others have mentioned, mice are a terrible model for this as their skin is very thin and proper tattooing is near impossible.
    • They mention verifying with human cadavers but don’t include any data from those.
    • There was no control group, the baseline was an untreated mouse, not one with an acute foot trauma.
    • Mice age very quickly, best I can tell the immunological markers weren’t age controlled. 2 months out of a <2 year lifespan is a lot of aging. Again, if there was a proper control to measure against.
    • The obsfucation of the raw data into cheesy and unreadable box and whisker plots is hella suspicious.

    At best it’s a very poorly communicated and poorly designed experiment but I suspect that’s due to it result hunting.


  • SinAdjetivos@lemmy.worldtoScience Memes@mander.xyzInsulin
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    18 days ago

    And it’s not just “overcrowded jails full of pretrial prisoners, the barefoot children carrying buckets for water in Appalachia” but the grad students in LA living out of their cars, or grandpa sleeping on a bus stop, or people in the Rockies surviving off roadkill and forage.

    Seattle tent cities/tiny homes make some Favelas look real swanky.










  • Institution based learning is can be unbelievably more effective.

    Institution based learning also creates a bunch of barriers primarily because “learning” is not the main purpose of a modern university.

    Those “professional educators” are often researchers moonlighting as educators, experts on their field, but rarely in addition to education. Their metrics are also not how well is material “taught” but to achieve a standard distribution of grades which can result in some real perverse incentives.

    Those “structured courses” have the same fundamental design flaw of primary education. They aren’t designed primarily for learning, they’re designed for factory work and obedience.

    That’s not touching on the more critical part of financial incentives and how financial strain, and excessive amounts of stress in general, is not conducive to a learning environment.

    Source: self made electric engineer thanks to the library and the dump.