Realistically their does need to be some consideration but the medium they travel isn’t air, but the occasional speck of dust, hydrogen atom, and other small stuff. It’s not much but for interstellar travel there are still considerations needed, namely reducing your cross sectional area in the direction of travel. Long and thin gives you less drag since it hits less stuff.
Regardless the airplane looks doesn’t make much sense anyway :)
For the sake of roleplay and being friends, the idea of disabled people in fantasy settings should not be difficult to accept, but that doesn’t mean that all fantasy IPs should have all sorts of modern disabilities. Like in a ttrpg you are creating a collaborative story using the ttrpg systems and in that sense heck yeah you can have magic chairs to transport otherwise disabled people. BG3 straight up cures blindness by use of a magical prosthetic eye, so there is even precedent for it in the popular dnd video game.
But what I totally want is some more creative and magical ways to handle disabilities, or maybe just whimsical. What about a druid that wildshapes into a snake to move around, and just slithers on the ground. straight up never uses a wheelchair cuz snek. Or magical leg armor. Prosthetic eyes? why not just have a large crystal ball that balances on your head that does the seeing for you.